Hypersensitivity to isosorbide dinitrate, to other nitrates or nitrites. Low filling pressure, hypertrophic obstructive cardiomyopathy, constrictive pericarditis, cardiac tamponade, cardiogenic shock, circulatory collapse, aortic &/or mitral valve stenosis, severe hypotension (systolic BP <90 mmHg), head trauma & cerebral hemorrhage, increased ICP-associated diseases, marked anemia, hypovolemia, closed-angle glaucoma. Use of phosphodiesterase inhibitors (eg, sildenafil, tadalafil, vardenafil).